Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Winter Edition, Bucuresti, Romanya, 26 - 28 Kasım 2025, ss.101-102, (Özet Bildiri)
Polyvinyl alcohol methacrylamide (PVA-MA) is a hydrogel derived from PVA, a synthetic polymer. PVA and methacrylate react to form methacrylated PVA (PVA-MA) with photo-crosslinking properties. The methacrylate double bond in PVA-MA is highly reactive and can easily cure when exposed to ultraviolet (UV) light. Hydrogels based on polyvinyl alcohol–methacrylic acid (PVA-MA) are biocompatible, mechanically durable, and capable of forming chemical cross-links due to the methacrylate groups in their structure. Thanks to these properties, they are widely used in biomedical applications. This study aimed to optimize the production parameters and curing conditions of PVA-MA-based hydrogel microneedles. The microneedles were produced using a DLP 3D printer. Polyvinyl alcohol–methacrylic acid (PVA-MA) was used as the matrix material to obtain the microneedles (MNs). The morphological analysis of the microneedles was performed using a scanning electron microscope (SEM), their molecular structures were characterized using a Fourier transform infrared (FTIR) spectrometer, and they were characterized using Nuclear Magnetic Resonance (NMR) methods. Additionally, their swelling and degradation behavior were investigated. Their mechanical strength was evaluated through compression testing. This study aims to contribute to the development of optimized, durable, and biocompatible microneedle systems for use in biomedical applications.