21523
Background: We aimed to investigate the clinical responses of local classical Kaposi's sarkoma (CKS) treated with different radiotherapy regimes. Methods: Fifteen patients with the diagnosis of CKS treated with radiotherapy were analyzed retrospectively. Total 19 lesions were irradiated. 13 (%68) were localized in lower extremity and 6 (%32) were in the other parts of the body. Depending on the tumor size, location and the depth, three different radiotherapy regimes were implemented. The total dose of 8 Gy was delivered to 14 (%71) of lesions either with 6–9 MeV electron or photon (Co60) beams in one fraction. 3 (%16) of the lesions were treated with 12Gy (6 Gy/day, in two days), and 2 (%11) of them treated with 20 Gy in 5 fractions. Boluses were adopted to improve the radiation distribution over the skin of lower extremities during treatment with Co60. All lesions were treated locally with a 2–3-cm safety margins. Results: The median of age was 70 (range: 41–80). The male: female ratio was 11/4. Median follow-up was 27 months. The lesions irradiated with 8 Gy were responded completely in a rate of %77. The complete response rates (CRR) with 12 Gy and 20 Gy were found to be %66 and %100, respectively. There was no CRR difference between the photon and electron beam treatment. CRR and overall survival rates were not statically different for the all three radiotherapy regimes. The tolerance to the treatment was high and the side effects were similar in all groups. Conclusions: Although the response rates seem to be high, the consideration of treatment results in a wide perspective is not satisfactory. Therefore plannig the new treatment regimes helps to increase the response rates of current treatment modalities.
No significant financial relationships to disclose.