MTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis

Caner M., BİRCAN R., Sevinc D., Benli F., Guney A. I. , Kurtoglu N.

GENETICS AND MOLECULAR BIOLOGY, cilt.31, sa.4, ss.836-838, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Konu: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1590/s1415-47572008005000023
  • Sayfa Sayıları: ss.836-838


Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease, i.e., significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.