Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity

Demir M. G., Altintoprak N., Aydin S., Kosemihal E., Basak K.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, cilt.11, sa.3, ss.202-206, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5152/iao.2015.1084
  • Dergi Adı: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.202-206
  • Anahtar Kelimeler: Melatonin, cisplatin, transtympanic, ototoxicity, cohlea, ANTIOXIDANT SYSTEM, PROTECTION, METABOLITE, RAT, GENERATION, RECEPTORS, MECHANISM, COCHLEA, CELLS
  • Marmara Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity.