Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity

Demir M. G., Altintoprak N., Aydin S., Kosemihal E., Basak K.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.11, no.3, pp.202-206, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.5152/iao.2015.1084
  • Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.202-206
  • Keywords: Melatonin, cisplatin, transtympanic, ototoxicity, cohlea, ANTIOXIDANT SYSTEM, PROTECTION, METABOLITE, RAT, GENERATION, RECEPTORS, MECHANISM, COCHLEA, CELLS
  • Marmara University Affiliated: Yes

Abstract

OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity.