1-Phenyl-5-substituted-3-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-pyrazole derivatives were synthesized from chalcone
derivatives. The structures of compounds were characterized by IR, 1H NMR spectroscopic methods and elemental
analysis. All compounds were evaluated for their in vitro antioxidant activity using DPPH and ABTS methods, anti-inflammatory
activity using lipoxygenase inhibitory method and antidiabetic activity using the α-glucosidase inhibitory
method. Especially, pyrazoline derivatives exhibited stronger anti-inflammatory activity than the reference drug indomethacin
(IC50: 50.45 μM) and their IC50 values were in the range of 0.68 and 4.45 μM. In addition, the ADME properties
of all chalcone and pyrazoline derivatives were calculated by Lipinski’s and Veber’s rules.