Akademik Veri Yönetim Sistemi
Scientific reports, cilt.16, sa.1, 2026 (SCI-Expanded, Scopus)
Neonatal jaundice is common and may lead to severe complications if not identified early. Although transcutaneous bilirubinometry (TcB) is widely used for noninvasive screening, its cost limits accessibility. Smartphone-based applications such as Picterus® Jaundice Pro (Picterus JP) may provide a low-cost alternative. We aimed to evaluate the correlation and agreement between Picterus JP and standard TcB measurements in newborns in Turkiye. This prospective observational study was conducted at a single tertiary center between December 2025 and January 2026. Newborns aged ≤ 7 days with gestational age ≥ 35 weeks were included. Paired TcB (Dräger JM-105) and Picterus JP measurements were obtained from the sternal area under standardized conditions. Correlation was assessed using Spearman's rank correlation. The agreement was evaluated using the Bland-Altman analysis and the concordance correlation coefficient (CCC). Clinically relevant disagreement was defined as an absolute difference ≥ 2 mg/dL. A total of 215 measurements from 165 newborns were analyzed. Median TcB and Picterus JP values were 6.7 mg/dL (IQR 4.85-8.9) and 7.0 mg/dL (IQR 5.3-9.9), respectively. Picterus JP showed a strong correlation with TcB (ρ = 0.78, p < 0.001). The mean bias (TcB-Picterus) was - 0.94 mg/dL, with 95% limits of agreement from - 5.35 to 3.47 mg/dL. The CCC was 0.73. Clinically acceptable agreement was highest at lower TcB levels and declined significantly at TcB ≥ 11 mg/dL. Picterus JP demonstrates good performance as a screening tool at low-to-moderate bilirubin levels but should not replace serum bilirubin measurement near treatment thresholds.