In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis


Mulazimoglu L. , Drenning S., Yu V.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.40, sa.10, ss.2428-2430, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 10
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1128/aac.40.10.2428
  • Dergi Adı: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  • Sayfa Sayıları: ss.2428-2430

Özet

Two oxazolidinones (U100592 and U100766), trovafloxacin, and a streptogramin combination (dalfopristin-quinupristin) were highly active in vitro against Staphylococcus aureus and Staphylococcus epidermidis, including methicillin-resistant strains. Trovafloxacin was more active than ciprofloxacin. Time-kill synergy studies demonstrated indifference for the oxazolidinones combined with vancomycin and rifampin against methicillin-resistant staphylococci. Spontaneous resistance was observed with all agents.