A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/beta-catenin pathway

Dogan A., Demirci S., Apdik H., Bayrak O. F., Gulluoglu Ş., Tuysuz E. C., ...Daha Fazla

METABOLISM-CLINICAL AND EXPERIMENTAL, cilt.69, ss.130-142, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.metabol.2017.01.021
  • Dergi Adı: METABOLISM-CLINICAL AND EXPERIMENTAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.130-142
  • Anahtar Kelimeler: Boron, Lipogenesis, beta-catenin, PPAR gamma, Adipogenesis, ADIPOCYTE DIFFERENTIATION, ADIPOSE-TISSUE, BORIC-ACID, ANTIOBESITY DRUGS, DIETARY BORON, MICE, NUTRITION, MODELS, ARREST, MASS
  • Marmara Üniversitesi Adresli: Hayır

Özet

Obesity is a worldwide medical problem resulting in serious morbidity and mortality involving differentiation of pre-adipocytes into mature adipocytes (adipogenesis). Boron treatment has been reported to be associated with weight reduction in experimental animals; however, its effects on pre-adipocyte differentiation and anti-adipogenic molecular mechanisms are unknown.