UV-Vis Spectrophotometric Investigation of Bupropion Hydrochloride-Generated Metal Complexes


Bakla M., Karaderi S. , Mazı C.

1ST INTERNATIONAL BALKAN CHEMISTRY CONGRESS (IBCC2018-Edirne)., Edirne, Türkiye, 17 - 20 Eylül 2018, cilt.1, ss.67

  • Cilt numarası: 1
  • Basıldığı Şehir: Edirne
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.67

Özet

Bupropion hydrochloride is an antidepressant originally approved for treatment of major depressive disorder in

1985. Currently, bupropion has US Food and Drug Administration (FDA) approved indications for treatment of

major depressive disorder, smoking cessation, seasonal affective disorder, and as an adjunct agent for weightloss

[1]. These metabolites exhibit pharmacological and toxico-logical activities in different preclinical

depression, behavioral and biochemical models as well as in humans. For example one of these, a number of

analytical methods have been identified, unlike the others. In the past, the stereoselective method was used to

measure bupropion and its three major tridecabolites, hydroxybupropion, erythro dihydrobupropion and dedihydrobupropion

using HPLC-MS / MS. A novel stereoselective liquid chromatography–tandem mass

spectrometry (LC–MS/MS) method was developed to separate andquantify enantiomers of bupropion, 4-

hydroxybupropion, and erythro- and threo-dihydrobupropion [2,3]. Based on a lot of research done in this

document prepared by the UV-VIS spectrophotometer developed method of analysis is included. The structures

of the metal complexes are supported by spectrophotometric method. Experimental data have shown that the

bupropion hydrochloride molecule can be tested by the improved UV-VIS spectrophotometric method. The

experimental data indicate the formation of metal:ligant 1:1 complexes for Ca-Bupropion hydrochloride and Mg-

Bupropion hydrochloride.