DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma

Ozdemir N., Celkan T., BARIŞ S., Batar B., Guven M.

LEUKEMIA RESEARCH, vol.36, no.5, pp.565-569, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1016/j.leukres.2011.10.012
  • Journal Name: LEUKEMIA RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.565-569
  • Keywords: Febrile neutropenia, XRCC1 and XPD polymorphisms, Mucositis, CANCER, ASSOCIATION, IMMUNODEFICIENCY, SUSCEPTIBILITY, CHEMOTHERAPY, RADIOTHERAPY, MORTALITY, TOXICITY, CAPACITY, ERCC2
  • Marmara University Affiliated: Yes

Abstract

The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association. (C) 2011 Elsevier Ltd. All rights reserved.