Leg ulcers and hydroxyurea: report of three cases with essential thrombocythemia

Demircay Z., Comert A., Adiguzel C.

INTERNATIONAL JOURNAL OF DERMATOLOGY, cilt.41, sa.12, ss.872-874, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Konu: 12
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1046/j.1365-4362.2002.01623.x
  • Sayfa Sayıları: ss.872-874


Case 1 A 65-year-old woman with essential thrombocythemia (ET) had been taking oral hydroxyurea (HU), 1000 mg daily, for 7 years. Six months ago, she developed an ulcer on the outer part of her left ankle, which healed spontaneously within 2 months. She presented with a new, tender, shallow ulcer, 2 cm x 2 cm in size, at the same site. Doppler examination revealed thrombosis of the left common femoral vein and a calcified atheroma plaque of the left common femoral artery. The dosage of HU was decreased to 500 mg daily when the platelet counts were found to be within normal levels. The ulcer completely healed within 2 months with occlusive wound dressings, and has not recurred within the follow-up period of 1 year.