Akademik Veri Yönetim Sistemi
Journal of the Australian Ceramic Society, 2025 (SCI-Expanded)
The aim of this study was to synthesize and to provide structural characterization along with preliminary biological assessment of the assemblies composed of bioactive glass, polysaccharides and monoammonium salt of glycyrrhizic acid (MSGA). Two different types of polysaccharides namely sodium carboxymethyl starch (CMS) and sodium carboxymethyl cellulose (CMC) were synthesized. The structural characterization of reactants and products was performed by means of Fourier transform infrared (FTIR) and scanning electron microscopy (SEM). The complex relationships between polysaccharides and BG components were revealed through the formation of hydrogen bonds and interaction of the carbonyl groups with the metal cations of BG. Finally, new assemblies were introduced to a culture of human osteoblast cell line (hFOB) in order to assess cytocompatibility. The obtained results demonstrated that CMS, with its branched structure, facilitates rapid water uptake and accelerated degradation, which can cause a burst release of glass-derived ions. Such spikes may lead to osmotic imbalances and abrupt pH shifts, contributing to the low viability (< 70%) of CMS-BG-MSGA series. In contrast, CMC features a linear, stable backbone that degrades more slowly and releases ions in a sustained manner.Thus, CMC-BG-MSGA compositions demonstrated 70% or high values of cell viability after incubation in a culture of human osteoblast cell line for 24 and 72 h. These promising results support the feasibility of further investigations involving osteogenic marker expression and in vivo implantation studies to evaluate the tissue regeneration potential of the developed materials.