Formation of new, cytocompatible hydrogels based on photochemically crosslinkable levan methacrylates

Berg A., Oner E. T., Combie J., Schneider B., Ellinger R., Weisser J., ...More

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol.107, pp.2312-2319, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107
  • Publication Date: 2018
  • Doi Number: 10.1016/j.ijbiomac.2017.10.120
  • Journal Name: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2312-2319
  • Keywords: Levan, Hydrogel, Photo-crosslinking, Mechanical properties, Cytocompatibility, PHOTOCROSSLINKABLE POLYSACCHARIDES, GLYCIDYL METHACRYLATE, DEXTRAN
  • Marmara University Affiliated: Yes

Abstract

Levan is a high molecular weight fructose-based biotechnologically available polysaccharide with a range of interesting properties qualifying this molecule for applications in biomedicine. In this study, new levan derivatives containing methacrylate groups attached either via ester or urethane linkages to the fructan backbone could be synthesized and structurally characterized by conventional analytical techniques. The photochemical crosslinking of these substances applying different photoinitiator systems and reaction conditions resulted in hydrogels of diverse properties which were investigated with regard to mechanical behaviour, hydrolytic degradability, and cytocompatibility. It was found that crosslinkable levan derivatives represent a new class of promising biopolymer-based macromers broadening the spectrum of available biomaterials to facilitate the adaption to the requirements of specific applications. (C) 2017 Elsevier B.V. All rights reserved.