Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol

Yasayan G. , Redhead M., Magnusson J. P. , Spain S. G. , Allen S., Davies M., ...Daha Fazla

POLYMER CHEMISTRY, cilt.3, sa.9, ss.2596-2604, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Konu: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1039/c2py20352a
  • Dergi Adı: POLYMER CHEMISTRY
  • Sayfa Sayıları: ss.2596-2604

Özet

Amphiphilic polymers have been synthesised by controlled free radical polymerisation techniques. These polymers self-assemble into well-defined vesicles in aqueous conditions, enabling encapsulation of a model hydrophilic molecule. The polymeric vesicles show high stability against a range of aqueous conditions with marginal release of cargo, even in the presence of known cell-membrane disruptive polymers such as branched poly(ethylene imine) (b-PEI). This stability allows for inversion of the surface charge of the polymeric vesicles by a simple coating protocol leading to an enhanced uptake by mammalian cells.