Atıf İçin Kopyala
Kaya Ö. T., Yıldız S. D., Levent N. H., Gürler E. B., Şehirli Ü. S., Şirvancı S.
Anatomy, cilt.14, sa.2, ss.111-116, 2020 (Hakemli Dergi)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
14
Sayı:
2
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Basım Tarihi:
2020
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Doi Numarası:
10.2399/ana.20.058
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Dergi Adı:
Anatomy
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Derginin Tarandığı İndeksler:
TR DİZİN (ULAKBİM)
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Sayfa Sayıları:
ss.111-116
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Marmara Üniversitesi Adresli:
Evet
Özet
Objectives: Neurogenesis is the formation process of functional neurons from progenitor cells which continues during life
time. Alterations in neurogenesis is associated with neurodegenerative disorders (ND). Different mechanisms underlie the ND
in males and females which may be related to neurogenesis. In this study, we aimed to investigate the developmental process
of neurogenesis in the hippocampus of male and female rats at different ages and shed light on the effect of gender dif
ference on ND.
Methods: Brains were obtained from 7, 14, 21 days and 3-month-old male and female Wistar rats following intracardiac per
fusion and processed for immunohistochemical and immunoflorescence staining. Doublecortin protein (DCX) was used as a
marker of newly-born neuroblasts to determine neurogenesis.
Results: DCX immunoreactive (-ir) cells were dispersed throughout the granular and subgranular layers of DG in 7-days-old
group in both genders. However, in the 14 and 21 days old groups, DCX-ir cells were observed only in the subgranular zone in
the sections labelled with both immunohistochemistry (IHC) and immunoflourescent (IF) methods. In all age groups, female rats
had a tendency to increase in DCX immunoreactivity when compared to that of male Wistar rats.
Conclusion: DCX-ir cells may be localized in different parts of DG during development. The number of newly born neurons
showed a tendency to increase in female rats in all groups. Further studies are needed to understand the reason for differ
ences in the normal developmental neurogenesis process between two genders.