Tacrolimus-Eluting Suture Inhibits Neointimal Hyperplasia: An Experimental In Vivo Study in Rats

Ak K., Ak E., Dericioglu O., Canak T., Akbuga J., Ozkan N., ...More

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, vol.53, no.3, pp.431-437, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ejvs.2016.11.027
  • Journal Name: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.431-437
  • Keywords: Eluting suture, Endothelialisation and anastomosis, Neointimal hyperplasia, Tacrolimus-chitosan, DRUG-DELIVERY, ANASTOMOTIC STRICTURE, INTIMAL HYPERPLASIA, GENE-TRANSFER, CANINE MODEL, PREVENTION, RESTENOSIS, GRAFTS, INJURY
  • Marmara University Affiliated: Yes

Abstract

Objective/Background: Neointimal hyperplasia (NIH) remains one of the leading causes of graft failure after vascular anastomoses. Cytotoxic drugs, such as rapamycin and tacrolimus, have been shown to inhibit the development of NIH. In this study, the aim was to test the impact of a sustained releasing tacrolimus-chitosan-eluting suture on the development of NIH in a rat model.