Tacrolimus-Eluting Suture Inhibits Neointimal Hyperplasia: An Experimental In Vivo Study in Rats

Ak K., Ak E., Dericioglu O., Canak T., Akbuga J., Ozkan N., ...Daha Fazla

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, cilt.53, sa.3, ss.431-437, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ejvs.2016.11.027
  • Dergi Adı: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.431-437
  • Anahtar Kelimeler: Eluting suture, Endothelialisation and anastomosis, Neointimal hyperplasia, Tacrolimus-chitosan, DRUG-DELIVERY, ANASTOMOTIC STRICTURE, INTIMAL HYPERPLASIA, GENE-TRANSFER, CANINE MODEL, PREVENTION, RESTENOSIS, GRAFTS, INJURY
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective/Background: Neointimal hyperplasia (NIH) remains one of the leading causes of graft failure after vascular anastomoses. Cytotoxic drugs, such as rapamycin and tacrolimus, have been shown to inhibit the development of NIH. In this study, the aim was to test the impact of a sustained releasing tacrolimus-chitosan-eluting suture on the development of NIH in a rat model.