The blockade of the renin-angiotensin system reverses tacrolimus related cardiovascular toxicity at the histopathological level

Agirbasli M., Papila-Topal N., Ogutmen B., Deniz H., Cakalagaoglu F., Tuglular S., ...Daha Fazla

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.8, sa.2, ss.54-58, 2007 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.3317/jraas.2007.009
  • Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.54-58
  • Anahtar Kelimeler: tacrolimus, cardiac toxicity, renin-angiotensin system, GROWTH-FACTOR-BETA, MESANGIAL CELLS, TGF-BETA, TRANSPLANT RECIPIENT, FK506 NEPHROTOXICITY, DIABETES-MELLITUS, CYCLOSPORINE-A, RATS, EXPRESSION, FIBROSIS
  • Marmara Üniversitesi Adresli: Evet

Özet

Introduction. In this study, we investigate the toxic effects of tacrolimus (FK506) on the cardiovascular system at the histopathological level in a rat model and whether these effects can be reversed by the blockade of the renin-angiotensin system (RAS) by either an angiotensin-converting enzyme inhibitor (ACE-inhibitors) or an angiotensin receptor antagonist (ARB).