3D-printed polylactic acid (PLA)/polymethyl silsesquioxane (PMSQ)-based scaffolds coated with vitamin E microparticles for the application of wound healing

Anjrini N., Karabulut H., ULAĞ S., Ege H., Noberi C., DOĞAN C., ...Daha Fazla

EMERGENT MATERIALS, cilt.7, sa.6, ss.2595-2604, 2024 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 6
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s42247-024-00711-3
  • Dergi Adı: EMERGENT MATERIALS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.2595-2604
  • Anahtar Kelimeler: Electrospray, Microparticles, PLA, PMSQ, Vitamin E, Wound healing, 3D printing
  • Marmara Üniversitesi Adresli: Evet

Özet

Skin is part of the integumentary and excretory system, which helps protect the body against infections. The skin should be properly treated when it gets injured, which requires a long healing process. In this study, 15% (w/v) polylactic acid (PLA) and 1 and 2% (w/v) polymethylsilsesquioxane (PMSQ) scaffolds were fabricated using 3D printing technology, and the surfaces of each scaffold were coated with 5% ethylcellulose (EC)/vitamin E microparticles using the electrospray method. The morphologies of the scaffolds were characterized using a scanning electron microscope (SEM), and results showed that the pore sizes of the scaffolds ranged from 136 to 265 μm. The vitamin E was completely released from the scaffolds within 5 h. MTT test was performed with fibroblast cells and results proved the biocompatibility of the scaffolds. These findings showed that the scaffolds may have good potential as a wound dressing material. The biodegradation test was performed in in vitro conditions and results showed that the surface coating with 5% EC/vitamin E microparticles on the 15% PLA/2% PMSQ scaffolds increased the degradation rate of the scaffolds.