T cell responses to 60/65 kDa heat shock protein derived peptides in Turkish patients with Behçet's disease.

Direskeneli H., Eksioglu-Demiralp E., Yavuz S., Ergun T., Shinnick T., Lehner T., ...Daha Fazla

The Journal of rheumatology, cilt.27, sa.3, ss.708-13, 2000 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2000
  • Dergi Adı: The Journal of rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.708-13
  • Anahtar Kelimeler: Behcet's disease, heat shock proteins, cellular immunity, IMMUNOHISTOLOGY, MYCOBACTERIAL, RECOGNITION, INDUCTION, EPITOPE, HSP
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective. Sequence homology and cross reactivity between microbial and human heal shuck proteins (HSP) led to the concept that HSP might be involved in the etiopathogenesis of Behcet's disease (BD). We investigated T cell responses to 8 synthetic peptides derived from the mycobacterial 65 kDa and homologous human 60 kDa HSP in patients with BD.