New in vitro effects of clopidogrel on platelets in hyperlipidemic and healthy subjects

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ÖZSAVCI D., ŞENER A., OBA R., Demirel G. Y., Uras F., Yardimci T. K.

TURKISH JOURNAL OF HEMATOLOGY, vol.27, no.2, pp.99-108, 2010 (SCI-Expanded, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 27 Issue: 2
• Publication Date: 2010
• Doi Number: 10.5152/tjh.2010.07
• Journal Name: TURKISH JOURNAL OF HEMATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.99-108
• Keywords: Platelets, hyperlipidemia, clopidogrel, apolipoprotein A1, apolipoprotein B, oxidative stress, nitrites, phosphatidylserine, P-selectin, glycoproteins IIb/IIIa, LOW-DENSITY-LIPOPROTEIN, GLYCOPROTEIN IIB/IIIA, P-SELECTIN, NORMOLIPEMIC VOLUNTEERS, SECONDARY PREVENTION, ACTIVATED PLATELETS, BINDING, INHIBITION, EXPRESSION, APOPTOSIS
• Marmara University Affiliated: Yes

Abstract

Objective: We aimed to detect novel in vitro effects of clopidogrel on platelets by assessment of the following parameters: malondialdehyde, glutathione, nitrite, aggregation response, and expressions of P-selectin, fibrinogen, apolipoprotein A1, apolipoprotein B, and phosphatidylserine.