The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level

ATALAN ÖZLEN N., Acar L., Yapici N., Kudsioglu T., Ergen A., Yilmaz S. G., ...Daha Fazla

IN VIVO, cilt.32, sa.6, ss.1653-1658, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.21873/invivo.11428
  • Dergi Adı: IN VIVO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1653-1658
  • Anahtar Kelimeler: Sepsis, TLR9, immunosuppression, toll-like receptors, INFLAMMATORY RESPONSE, HOST-DEFENSE, CPG DNA, INNATE, TOLL-LIKE-RECEPTOR-9, LIPOPOLYSACCHARIDE, CONTRACTILITY, DEFINITIONS, DYSFUNCTION, PNEUMONIAE
  • Marmara Üniversitesi Adresli: Evet

Özet

Background/Aim: Our aim was to determine serum TLR-9 levels in sepsis and evaluate the relationship between sepsis and serum TLR-9 levels. Materials and Methods: The study group consisted of 80 consecutive patients with sepsis and 100 healthy individuals. The demographic characteristics, co-morbidities and hemodynamic data of all patients were recorded. Results: TLR-9 serum levels in sepsis were statistically significantly lower compared to the control group. It was also seen that when the lactate level was >5 mmol/l in patients in the sepsis group, the serum TLR-9 levels were substantially higher. Conclusion: There is a relationship between sepsis-induced immunosuppression and serum TLR-9 levels. The host immunity system can be activated by means of TLR-9-related systems, while hyperlactatemia may play a stimulating role in the re-activation of the immune system.