Childhood myelodysplastic syndrome progressing to Pre-B acute lymphoblastic leukemia in two children with trisomy 5 and trisomy 8 Trizomi 5 ve Trizomi 8'li İki Çocukta Pre-B Akut Lenfoblastik Lösemiye İlerleyen Çocukluk Çağı Miyelodisplastik Sendromu

YILMAZ B., KOÇ A.

Turkiye Klinikleri Pediatri, cilt.30, sa.2, ss.156-159, 2021 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.5336/pediatr.2020-80991
  • Dergi Adı: Turkiye Klinikleri Pediatri
  • Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.156-159
  • Anahtar Kelimeler: Acute lymphoblastic leukemia, Childhood, Myelodysplastic syndrome, Trisomy 5, Trisomy 8
  • Marmara Üniversitesi Adresli: Evet

Özet

Myelodysplastic syndrome (MDS) is a rare disorder in childhood. It is often characterized by cytopenias, morphological dysplastic changes, functional abnormalities in hematopoietic cells, and an increased risk for acute myeloid leukemia (AML). Transformation of MDS into AML can often be seen, but the transformation into acute lymphoblastic leukemia (ALL) is extremely rare in childhood. Previously only a few cases have been reported in the literature. In this article, we presented a 7-year-old female patient with trisomy 5 cytogenetic abnormality who developed ALL 9 months after the diagnosis of MDS, and a 6-year-old female patient with trisomy 8 cytogenetic abnormality who developed ALL 4 months after the diagnosis of MDS.