Octreotide improves burn-induced intestinal injury in the rat

Sener G., Sehirli A., Satiroglu H., Kacmaz A., Ayanoglu-Dulger G., Yegen B.

PEPTIDES, cilt.24, sa.1, ss.123-127, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0196-9781(02)00284-x
  • Dergi Adı: PEPTIDES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-127
  • Marmara Üniversitesi Adresli: Evet

Özet

The local thermal trauma activates a number of systemic mediator cascades, e.g. a complement activation, cytokine production, resulting in a generalized sequestration and a priming of local and systemic neutrophils and macrophages. We aimed to determine the possible protective effect of octreotide (OCT), a synthetic somatostatin analogue, against burn-induced intestinal tissue damage possibly by inhibiting neutrophil infiltration.