Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro

Johnson N. W., ÖZKAN M., Burgess A. P., Prokic E. J., Wafford K. A., O'Neill M. J., ...Daha Fazla

NEUROPHARMACOLOGY, cilt.119, ss.141-156, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 119
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.neuropharm.2017.04.009
  • Dergi Adı: NEUROPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.141-156
  • Anahtar Kelimeler: Neuronal network oscillations, M1, Theta, Gamma, Phase amplitude coupling, PARVALBUMIN-POSITIVE INTERNEURONS, NITRIC-OXIDE SYNTHASE, ENTORHINAL CORTEX, HIPPOCAMPAL-FORMATION, NETWORK OSCILLATIONS, RECEPTOR ACTIVATION, BEHAVING RAT, NEURONAL OSCILLATIONS, CORTICAL OSCILLATIONS, SOMATOSENSORY CORTEX
  • Marmara Üniversitesi Adresli: Evet

Özet

In vivo, theta (4-7 Hz) and gamma (30-80 Hz) neuronal network oscillations are known to coexist and display phase-amplitude coupling (PAC). However, in vitro, these oscillations have for many years been studied in isolation. Using an improved brain slice preparation technique we have, using co-application of carbachol (10 mu M) and kainic acid (150 nM), elicited simultaneous theta (6.6 +/- 0.1 Hz) and gamma (36.6 +/- 0.4 Hz) oscillations in rodent primary motor cortex (M1). Each oscillation showed greatest power in layer V. Using a variety of time series analyses we detected significant cross-frequency coupling in 74% of slice preparations.