Synthesis and structure elucidation of some new thioether derivatives of 1,2,4-triazoline-3-thiones and their antimicrobial activities

Gulerman N., Dogan H., Rollas S., Johansson C., Celik C.

FARMACO, vol.56, no.12, pp.953-958, 2001 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 12
  • Publication Date: 2001
  • Doi Number: 10.1016/s0014-827x(01)01167-3
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.953-958
  • Keywords: 1,2,4-triazole derivatives, synthesis, antibacterial, antifungal, antimycobacterial activities, ANTIFUNGAL ACTIVITIES, ANTIBACTERIAL, THIOSEMICARBAZIDES, ANTIMYCOBACTERIAL
  • Marmara University Affiliated: No

Abstract

5-(4-Pyridinyl)-4-substituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 5-(4-pyridinyl)-4-substituted-3-(benzoylmethyl)thio 4H-1,2,4-triazoles were synthesized. The structures of original nine compounds were confirmed by IR, H-1 NMR, mass spectral methods and elemental analysis. The antibacterial, antifungal and antimycobacterial activities, together with those of known intermediate 1,4-disubstituted thiosemicarbazides, were reported. (C) 2001 Elsevier Science S.A. All rights reserved.