Levofloxacin for the treatment of severe refractory BK virus-associated hemorrhagic cystitis in hematopoietic stem cell transplantation recipients: A report of three cases

Toptas T., Kaygusuz-Atagunduz I., KANİ H. T., Adiguzel C., Firatli-Tuglular T.

ONCOLOGY LETTERS, cilt.8, sa.4, ss.1775-1777, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3892/ol.2014.2381
  • Dergi Adı: ONCOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1775-1777
  • Anahtar Kelimeler: BK virus, hemorrhagic cystitis, levofloxacin, hematopoietic stem cell transplantation, BONE-MARROW TRANSPLANTATION, RENAL-TRANSPLANTATION, PREVENTION, VIREMIA
  • Marmara Üniversitesi Adresli: Evet

Özet

BK-virus (BKV) is an important etiological agent for late-onset hemorrhagic cystitis (HC) in patients undergoing hematopoietic stem cell transplantation. Late-onset HC causes significant morbidity among these patients. Therapeutic approaches remain predominantly symptomatic. Several treatment options have been used with variable success rates. Cidofovir has the highest specificity against BKV; however, its lack of availability in the majority of countries, high costs and potential nephrotoxic effects limit its,use. The present study reports three cases of severe and prolonged BKV-associated HC (BKHC). HC was resolved in all three of the patients using oral levofloxacin. Thus, levofloxacin may be an effective treatment modality for achieving complete clinical and molecular response in patients with refractory, severe BKHC.