Increased hippocampal CA1 cerebral blood volume in schizophrenia

Talati P., Rane S., KÖSE A. , Blackford J. U. , Gore J., Donahue M. J. , ...Daha Fazla

NEUROIMAGE-CLINICAL, cilt.5, ss.359-364, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.nicl.2014.07.004
  • Sayfa Sayıları: ss.359-364


Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied 15 schizophrenia patients and 15 matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to the long axis of the hippocampus. The subfields of the hippocampal formation (subiculum, CA1, CA2/3, and hilus/dentate gyrus) were manually segmented to establish CBV values. Comparing anterior CA1 and CA2/3 CBV between patients and controls revealed a significant subfield-by-diagnosis interaction. This interaction was due to the combined effect of a trend of increased CA1 CBV (p =.06) and non-significantly decreased CA2/3 CBV (p = 0.14) in patients relative to healthy controls. These results support the emerging hypothesis of increased hippocampal activity as a biomarker of schizophrenia and highlight the importance of subfield-level investigations. (C) 2014 The Authors. Published by Elsevier Inc.