Synthesis, Complexation, and Biological Activity Studies of 4-Aminomethyl-7,8-dihydroxy Coumarines and Their Crown Ether Derivatives


GÜMÜŞ PALABIYIK A., Karadeniz S., Ugras H. I., Bulut M., ÇAKIR Ü., Goren A. C.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.47, sa.5, ss.1127-1133, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/jhet.435
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1127-1133
  • Marmara Üniversitesi Adresli: Evet

Özet

The article focuses synthesis of novel 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives. The purified novel coumarins and their crown ether derivatives were identified by (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis. The 1:1 binding constants of Ca(2+), Mg(2+), Fe(2+), Zn(2+), Ni(2+), Cd(2+), Co(2+), and Mn(2+) ions at 25 degrees C +/- 0.1 with the 4-aminomethyl-7,8-dihydroxy coumarins and their crown ether derivatives estimated using extraction procedure with Inductively Coupled Plasma-Atomic Emission Spectroscopy in dichloromethane/water membrane systems. Synthesized compounds were investigated for complexation and biological activity properties. Best results in biological activity studies were observed for antioxidant activity.