EFFECT OF ANTIEPILEPTIC DRUGS ON ERYTHROCYTE OSMOTIC FRAGILITY AND LIPID-PEROXIDATION

YALCIN A., ONARAN I., YALCIN A. S.

EPILEPSY RESEARCH, cilt.19, sa.3, ss.249-252, 1994 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0920-1211(94)90069-8
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.249-252
  • Marmara Üniversitesi Adresli: Evet

Özet

Epileptic children receiving antiepileptics were studied to investigate the effect of carbamazepine and phenobarbital therapy on erythrocyte osmotic fragility and lipid peroxidation. Significant differences between the two groups were observed in erythrocyte osmotic fragility. In addition, there was a significant increase in erythrocyte malondialdehyde release in the epileptic group compared to controls. It is suggested that the use of antioxidants in addition to antiepileptic drugs may be beneficial.