EFFECT OF ANTIEPILEPTIC DRUGS ON ERYTHROCYTE OSMOTIC FRAGILITY AND LIPID-PEROXIDATION


YALCIN A., ONARAN I., YALCIN A. S.

EPILEPSY RESEARCH, cilt.19, ss.249-252, 1994 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 3
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0920-1211(94)90069-8
  • Dergi Adı: EPILEPSY RESEARCH
  • Sayfa Sayıları: ss.249-252

Özet

Epileptic children receiving antiepileptics were studied to investigate the effect of carbamazepine and phenobarbital therapy on erythrocyte osmotic fragility and lipid peroxidation. Significant differences between the two groups were observed in erythrocyte osmotic fragility. In addition, there was a significant increase in erythrocyte malondialdehyde release in the epileptic group compared to controls. It is suggested that the use of antioxidants in addition to antiepileptic drugs may be beneficial.