Akademik Veri Yönetim Sistemi
13th EFSMA Congress of Sports Medicine, Bucuresti, Romanya, 25 - 27 Eylül 2025, ss.20, (Yayınlanmadı)
Glioblastoma (GBM) is an aggressive brain tumor in adults, associated with cognitive impairment. The standard chemotherapeutic agent is temozolomide (TMZ). This study aimed to evaluate the effects of exercise and/or TMZ on cognitive and motor functions and underlying mechanisms in a GBM model.
Fifty male Sprague Dawley rats were randomly assigned to five groups: Sham, GBM, GBM+TMZ, GBM+Exercise, and GBM+TMZ+Exercise. GBM was induced via intracerebral injection of glioma cells. TMZ (10 mg/kg) was administered by oral gavage for 5 days. Exercise groups underwent moderate intensity (50-60%VO₂max) treadmill running for 8 weeks. Cognitive and motor functions, anxiety- and depression-like behaviors were assessed using the Y-maze, open field, hole-board, sucrose preference tests. Brain malondialdehyde (MDA) and glutathione levels, myeloperoxidase (MPO), superoxide dismutase (SOD) and catalase (CAT) activities, and histological analysis were done. Brain weight index was calculated. Data were analyzed using ANOVA and Student’s t-test.
The decline in spatial memory of GBM group was improved with exercise and TMZ (p<0.05-0.01). Motor functions were improved in TMZ and/or exercise groups (p<0.05-0.01). Anxiety-like behavior was increased in GBM, suppressed with exercise (p<0.05-0.001). Sucrose preference was higher in TMZ and TMZ+Exercise groups versus GBM and control groups (p<0.05-0.01). Brain weight index decreased in GBM and risen with exercise (p<0.05-0.001). MDA and MPO levels were increased in GBM and decreased in all other groups (p<0.05-0.01). SOD activity was higher in exercise and/or TMZ groups (p<0.05-0.01). CAT activity was improved with TMZ (p<0.01). Neuronal damage was alleviated in Exercise and TMZ+Exercise groups.
GBM diminished spatial memory, aggravated anxiety- and depression-like behavior, elevated oxidative stress. Aerobic exercise and/or TMZ improved cognitive and motor function, anxiety- and depression-like behavior. Exercise enhanced brain SOD activity and suppressed oxidative damage. TMZ improved SOD and CAT capacities and repressed oxidative damage. Our results suggest exercise as a supportive treatment in GBM.