Atıf İçin Kopyala
Stephenson A., Eszlinger M., Stewardson P., Mcıntyre J. B., Boesenberg E., Bircan R., ...Daha Fazla
THYROID, cilt.30, ss.1482-1489, 2020 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
30
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Basım Tarihi:
2020
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Doi Numarası:
10.1089/thy.2019.0648
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Dergi Adı:
THYROID
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
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Sayfa Sayıları:
ss.1482-1489
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Anahtar Kelimeler:
thyroid nodules, TSH receptor, GNAS, genetics, prevalence, SOMATIC MUTATIONS, POINT MUTATIONS, GENE, PREVALENCE, IDENTIFICATION, ACTIVATION, ADENOMAS, DNA
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Marmara Üniversitesi Adresli:
Evet
Özet
Background: Constitutively activating mutations in the thyrotropin receptor (TSHR) and the guanine nucleotide-binding protein G subunit alpha (GNAS) are the primary cause of hot thyroid nodules (HTNs). The reported prevalence of TSHR and GNAS mutations in HTNs varies. Previous studies show TSHR mutations in 8-82% of HTNs and GNAS mutations in 8-75% of HTNs. With sensitive and comprehensive targeted next-generation sequencing (tNGS), we re-evaluated the prevalence of TSHR and GNAS mutations in HTNs.