The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, cilt.28, sa.1, ss.66-72, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 1
- Basım Tarihi: 2018
- Doi Numarası: 10.1080/24750573.2017.1380920
- Dergi Adı: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.66-72
- Anahtar Kelimeler: Schizophrenia, inflammation, cytokines, cognition, psychopathology, 1ST EPISODE PSYCHOSIS, SYNDROME SCALE PANSS, C-REACTIVE PROTEIN, MEDICATION-NAIVE, SERUM-LEVELS, METAANALYSIS, SYMPTOMS, INFLAMMATION, IMPAIRMENT, INDIVIDUALS
- Marmara Üniversitesi Adresli: Evet
Özet
OBJECTIVES: Inflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions).