The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia


Ergun S. , YANARTAŞ Ö. , Kandemir G., Yaman A., YILDIZ M. , HAKLAR G. , ...More

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.28, no.1, pp.66-72, 2018 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1080/24750573.2017.1380920
  • Title of Journal : PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Page Numbers: pp.66-72

Abstract

OBJECTIVES: Inflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions).