Journal of endocrinological investigation, vol.40, no.12, pp.1365-1372, 2017 (Journal Indexed in SCI Expanded)
Article / Article
Title of Journal :
Journal of endocrinological investigation
Acromegaly, Depressive mood, Cognitive functions, QUALITY-OF-LIFE, GROWTH-FACTOR-I, LONG-TERM CURE, PITUITARY-TUMORS, HORMONE EXCESS, RADIOTHERAPY, IMPAIRMENT, BRAIN, COMPLICATIONS, DYSFUNCTION
Aims Acromegaly is caused by a pituitary adenoma that releases excess growth hormone (GH) and a concomitant increase in insulin-like growth factor 1 (IGF-1). Acromegaly results not only in phenotypic changes, but also in neurologic complications as peripheral neuropathy and cognitive dysfunction. This study aimed to compare depressive mood and cognitive function in patients with acromegaly and in healthy controls as well as to determine the factors underlying cognitive dysfunction in the acromegalic patients.