alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats


Sehirli O., Sener E. , Cetinel U. , Yueksel M. , Gedik N., Sener G.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.35, no.3, pp.249-255, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1440-1681.2007.04810.x
  • Title of Journal : CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Page Numbers: pp.249-255
  • Keywords: cytokines, ischaemia-reperfusion, kidney, alpha-lipoic acid, myeloperoxidase, ISCHEMIA/REPERFUSION INJURY, SUPEROXIDE-DISMUTASE, OXIDATIVE STRESS, REACTIVE OXYGEN, FREE-RADICALS, AGED RATS, FAILURE, ANTIOXIDANT, MYELOPEROXIDASE, INFLAMMATION

Abstract

1. Oxygen free radicals are important components involved in the pathophysiological processes observed during ischaemia-reperfusion (I/R). The present study was designed to assess the possible protective effect of et-lipoic acid (ALA) on renal I/R injury.