Design and fabrication of electrospun polycaprolactone/chitosan scaffolds for ligament regeneration


Saatcioglu E., Ulag S., Şahin A., Yılmaz B., Ekren N., İnan A. T., ...More

EUROPEAN POLYMER JOURNAL, vol.148, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 148
  • Publication Date: 2021
  • Doi Number: 10.1016/j.eurpolymj.2021.110357
  • Journal Name: EUROPEAN POLYMER JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Anterior cruciate ligament (ACL), Chitosan, PCL, Ligament, Scaffold
  • Marmara University Affiliated: Yes

Abstract

Tendon and ligament impairments are among the most familiar injuries of the knee with acute or chronic pain conditions. The defects of anterior cruciate ligament (ACL) stay a known clinical problem. In the present study, the electrospinning method was used to fabricate 10wt.%PCL/(1, 3, 5)wt.%Chitosan (CS) appropriate and biocompatible scaffolds with a similar connective ligament geometry and structure. 10wt.%PCL/3wt.%CS demonstrated higher tensile strength value (0.58854 MPa) than other scaffolds in the tensile test.