Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer


AKKİPRİK M. , Feng Y., Wang H., Chen K., Hu L., Sahin A., ...More

BREAST CANCER RESEARCH, vol.10, no.4, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 10 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1186/bcr2116
  • Title of Journal : BREAST CANCER RESEARCH

Abstract

The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.