In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: assessment by tissue collagen content and prolidase activity.

Tarcin O., Avsar K., Demirturk L., Gultepe M., Oktar B., Ozdogan O. C., ...Daha Fazla

Journal of gastroenterology and hepatology, cilt.18, sa.4, ss.437-44, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1046/j.1440-1746.2003.03004.x
  • Dergi Adı: Journal of gastroenterology and hepatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.437-44
  • Anahtar Kelimeler: antifibrotic, bile duct ligation, combination, hepatic fibrosis, interferon-alpha, pentoxifylline, prolidase, rat, BILE-DUCT OBSTRUCTION, LIVER FIBROSIS, QUANTITATIVE ASSESSMENT, HISTOLOGICAL ACTIVITY, MORPHOMETRIC METHOD, EXPERIMENTAL-MODEL, PLASMA PROLIDASE, SCORING SYSTEM, SERUM MARKERS, C PATIENTS
  • Marmara Üniversitesi Adresli: Evet

Özet

Background and Aim: To evaluate the possible antifibrotic effects of two drugs, pentoxifylline (PTX) and interferon (IFN)-alpha as well as their combination, on a bile-duct-ligated rat hepatic fibrosis model.