Serum osteoprotegerin levels, endothelial function and carotid intima-media thickness in type 2 diabetic patients

Gunes M., Temizkan S., Apaydin T., Ilgin C., Haklar G., Gogas Yavuz D.

JOURNAL OF DIABETES AND ITS COMPLICATIONS, cilt.35, sa.12, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.jdiacomp.2021.108073
  • Dergi Adı: JOURNAL OF DIABETES AND ITS COMPLICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Anahtar Kelimeler: Type 2 diabetes mellitus, Osteoprotegerin, Flow-mediated dilation, Endothelial function, Carotid intima-media thickness, VASCULAR CALCIFICATION, PLASMA OSTEOPROTEGERIN, MYOCARDIAL-INFARCTION, PREDICTIVE-VALUE, ARTERY-DISEASE, TASK-FORCE, ATHEROSCLEROSIS, DYSFUNCTION, RISK, VASODILATION
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives: Osteoprotegerin (OPG), a well-known protein that inhibits osteoclast formation and activity, might also be a potential marker for identifying patients with high cardiovascular risk. This study aimed to compare OPG levels, FMD, and CIMT measurements in subjects with vs. without diabetes and investigate the association of serum osteoprotegerin level with the early atherosclerotic markers, endothelial function, and carotid intimamedia thickness (CIMT) in patients with type 2 diabetes mellitus (DM2).