Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Behcet's disease and recurrent aphthous ulcerations


PEKİNER F. M. , AYTUGAR E., Demirel G. Y. , BORAHAN M. O.

JOURNAL OF ORAL PATHOLOGY & MEDICINE, vol.41, no.1, pp.73-79, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1600-0714.2011.01061.x
  • Title of Journal : JOURNAL OF ORAL PATHOLOGY & MEDICINE
  • Page Numbers: pp.73-79
  • Keywords: Behcet's disease, cytokine, IL-2, IL-6, recurrent aphthous ulcerations, T regulatory cell, NECROSIS-FACTOR-ALPHA, IMMUNOLOGICAL-TOLERANCE, TNF-ALPHA, EXPRESSION, CYTOKINES, IL-6, RECEPTOR, LESIONS, FOXP3, GAMMA

Abstract

BACKGROUND: One of the factors involved in the pathogenesis of Behcet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.