Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

Takir, Mumtaz; Kostek, OSMAN; Ozkok, Abdullah; ELÇİOĞLU, Ömer; Bakan, Ali; Erek, Aybala; MUTLU, HASAN; Telci, Ozge; Semerci, Aysun; ODABAŞ, ALİ; Afsar, Baris; Smits, Gerard; ALanaspa, Miguel; Sharma, Shailendra; Johnson, Richard; Kanbay, Mehmet

doi:10.1097/jim.0000000000000242

Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

Takir M., Kostek O., Ozkok A., ELÇİOĞLU Ö. C., Bakan A., Erek A., ...Daha Fazla

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.63, sa.8, ss.924-929, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 63 Sayı: 8
Basım Tarihi: 2015
Doi Numarası: 10.1097/jim.0000000000000242
Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.924-929
Anahtar Kelimeler: uric acid, allopurinol, insulin resistance, inflammation, EXCESSIVE FRUCTOSE INTAKE, METABOLIC SYNDROME, OXIDATIVE STRESS, GLOMERULAR HYPERTENSION, POTENTIAL-ROLE, FATTY-LIVER, GLUCOSE, OBESITY, SIGNAL, RATS
Marmara Üniversitesi Adresli: Hayır

Özet

Background Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.