Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats


Toklu H. Z. , Sehirli O., Ersahin M., Suleymanoglu S., Yiginer O., Emekli-Alturfan E. I. , ...More

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.62, no.12, pp.1784-1793, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 12
  • Publication Date: 2010
  • Doi Number: 10.1111/j.2042-7158.2010.01197.x
  • Title of Journal : JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Page Numbers: pp.1784-1793
  • Keywords: hypertension, Na+/K+-ATPase, oxidative stress, resveratrol, WINE POLYPHENOL RESVERATROL, RENIN-ANGIOTENSIN SYSTEM, RED WINE, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, ENDOTHELIAL DYSFUNCTION, INDUCED CARDIOTOXICITY, VASCULAR DYSFUNCTION, NADPH OXIDASE, CAUSAL ROLE

Abstract

Objectives The putative protective effects of resveratrol against oxidative injury in the heart, kidney and brain tissues of rats induced with the two-kidney, one-clip (2K1C) hypertension model were investigated.