Comparison of pulmonary functions and quality of life in patients with parkinson’s disease and multiple system atrophy


European Respiratory Society ERS International Congress Virtuel 2020, 7 - 09 September 2020, vol.56 identifier


Introduction: Parkinson's disease (PD) and Multiple Sistem Atrophy (MSA) are the most common neurodegenerative diseases. Although PD and MSA have been compared in terms of many clinical parameters in recent years, there is a limited number of studies comparing pulmonary functions and quality of life (QoL).

Aim: The aim of this study is to compare pulmonary functions and QoL in patients with PD and MSA.

Methods: Participants’ demographic information was obtained, pulmonary functions were performed by spirometry and respiratory muscle strength was assessed with maximal inspiratory and expiratory mouth pressure (respectively MIP and MEP). SF-36 was used for the assessment of QoL.

Results: In our study 22 patients (13 PD, Females 4, Males 9, age:62,0±8,3 years; 9 MSA, Females 5, Males 4 age:62,5±10 years) and 12 healthy volunteers (Females 8, Males 4, age:58,7±8,9 years) were evaluated. There was a statistical difference within PD, MSA and healthy groups in pulmonary functions (FEV1/FVC, MIP%, FVC%, PEF%) (p<0.05). Also, there were significant differences between SF-36 subscale scores within groups (p<0.05) except for the mental health and vitality subscale scores (p>0.05). Pulmonary function results and SF-36 subscale scores were significant in favor of healthy group (p<0.05).

Conclusion: Pulmonary functions decreased in both PD and MSA groups compared to healthy subjects group. These findings suggest that clinicians should include pulmonary and QoL assessment even in the early phase of PD and MSA diseases. Decreased pulmonary functions may be affect the QoL in these people. Furthermore, future studies should investigate the effect of pulmonary rehabilitation in patients with PD and MSA.