Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering


Aydogdu M. O. , Chou J., Altun E., EKREN N. , Cakmak S., Eroglu M., ...More

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.68, no.5, pp.243-255, 2019 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1080/00914037.2018.1443930
  • Title of Journal : INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Page Numbers: pp.243-255
  • Keywords: Cardiovascular tissue engineering, collagen, electrospinning, ethyl cellulose, polycaprolactone, SCAFFOLD, PROLIFERATION, FABRICATION, NANOFIBERS, HEPARIN, PATIENT, GRAFTS

Abstract

A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability.