Protective role of resveratrol against cisplatin induced ototoxicity in guinea pigs

YUMUŞAKHUYLU, ALİ; Yazici, Mine; Sari, Murat; Binnetoglu, Adem; Kosemihal, Ebru; Akdas, Ferda; ŞİRVANCI, SERAP; YÜKSEL, MERAL; Uneri, Cuneyd; Tutkun, Alper

doi:10.1016/j.ijporl.2011.12.021

Protective role of resveratrol against cisplatin induced ototoxicity in guinea pigs

YUMUŞAKHUYLU A. C. , Yazici M., Sari M., Binnetoglu A., Kosemihal E., Akdas F., ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.76, no.3, pp.404-408, 2012 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 76 Issue: 3
Publication Date: 2012
Doi Number: 10.1016/j.ijporl.2011.12.021
Title of Journal : INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
Page Numbers: pp.404-408
Keywords: Resveratrol, Cisplatin, Ototoxicity, Auditory brainstem response, Reactive oxygen species, Scanning electron microscopy, ROUND WINDOW APPLICATION, D-METHIONINE, HAIR-CELLS, VITAMIN-E, ANTIOXIDANT, NEPHROTOXICITY, EXPRESSION, GROWTH, RATS

Abstract

Objective: The aim of this study was to evaluate the effectiveness of systemic administration of resveratrol against cisplatin-induced ototoxicity in guinea pigs.