Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease


Agirbasli M., Guney A. I., Ozturhan H. S., Agirbasli D., Ulucan K., Sevinc D., ...Daha Fazla

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, cilt.18, sa.6, ss.803-809, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/1741826711398806
  • Dergi Adı: EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.803-809
  • Anahtar Kelimeler: ACE I/D, coronary artery disease, eNOS 3-27, Gln192Arg PON1, MTHFR C677T, multifactor dimensionality reduction, PAI-1 4G/5G, EPISTASIS
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Association studies in the Turkish population have investigated the single locus effects of different gene polymorphisms on coronary artery disease (CAD). CAD is a complex polygenic disease that involves complex interactions among multiple genetic and environmental conditions.