Epicardial adipose tissue thickness in type 1 diabetic patients

Yazici D., ÖZBEN SADIÇ B., YAVUZ D., Deyneli O., Aydin H., TARÇIN Ö., ...More

ENDOCRINE, vol.40, no.2, pp.250-255, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1007/s12020-011-9478-x
  • Journal Name: ENDOCRINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.250-255
  • Keywords: Epicardial adipose tissue thickness, Type 1 diabetes mellitus, Insulin resistance, Estimated glucose disposal rate, CARDIOVASCULAR RISK-FACTORS, CORONARY-HEART-DISEASE, METABOLIC SYNDROME, INSULIN-RESISTANCE, PITTSBURGH EPIDEMIOLOGY, FAT, COMPLICATIONS, SEVERITY, ECHOCARDIOGRAPHY, ASSOCIATION
  • Marmara University Affiliated: Yes

Abstract

Insulin resistance is getting important in the course of type 1 diabetes mellitus. Visceral fat depot is associated with insulin resistance and assessment of epicardial fat thickness is a way of measuring visceral fat. The aim of the study was to measure epicardial adipose tissue (EAT) thickness and to determine its relationship with waist-hip-ratio (WHR) and estimated glucose disposal rate (eGDR) in adult type 1 diabetic patients. Thirty-six type 1 diabetic patients (aged 31 +/- 8 years; Female/Male: 22/14) and 43 age, gender and BMI matched healthy controls were included. Fasting blood glucose (FBG), hemoglobin A1c, and lipid profiles were measured. Waist-hip-ratio (WHR) was calculated. Daily insulin dose/kg of patients were recorded and eGDR of all subjects was calculated. Epicardial adipose tissue (EAT) thickness was evaluated by echocardiography. EAT thickness of the type 1 diabetic patients was significantly higher than controls (3.30 +/- 1.06 vs. 2.30 +/- 0.34 mm, P < 0.0001). EAT thickness was correlated with age (P = 0.05; r = 0.35), WHR (P = 0.003; r = 0.67), daily insulin dose/kg (r = 0.45, P = 0.005), and eGDR (r = -0.55, P = 0.0004). Multivariate analysis revealed WHR and eGDR to be related to EAT among age, WHR, daily insulin dose/kg, eGDR, FBG, and hemoglobin A1c (r(2) of the model = 0.64). Epicardial adipose tissue thickness is increased in type 1 diabetic patients compared to controls and is related to WHR and eGDR in this group of patients. This measurement may point to the presence of insulin resistance in type 1 diabetic patients.