FTO mRNA Expression in Extremely Obese and Type 2 Diabetic Human Omental and Subcutaneous Adipose Tissues

Susleyici-Duman B., Zengin K., KAYHAN F. E., Koldemir M., Dagistanli F. K., Cagatay P., ...More

OBESITY SURGERY, vol.21, no.11, pp.1766-1773, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 11
  • Publication Date: 2011
  • Doi Number: 10.1007/s11695-011-0446-6
  • Journal Name: OBESITY SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1766-1773
  • Keywords: FTO expression, Subcutaneous fat, Omental fat, Morbid obesity, Adiposity, CD68, Drug, ACID-BINDING PROTEIN, GENE-EXPRESSION, INSULIN SENSITIVITY, FAT, ACCUMULATION, MACROPHAGES, RESISTANCE, PROFILE, MUSCLE, MEMBER
  • Marmara University Affiliated: Yes

Abstract

Fat mass and obesity-associated protein (FTO) gene expression is known to correlate with obesity. Our aim was to investigate the FTO gene expression in paired omental and subcutaneous human adipose tissues from morbid and obese patients. To understand the role of CD68-positive macrophages in adipose tissues, the correlation with adiposity parameters such as adipocyte diameter and adipocyte radius was also measured. Drug and adiposity correlations were also analyzed.