The Biochemical, Histopathological and Clinical Comparison of the Neuroprotective Effects of Subcutaneous Adalimumab and Intravenous Methylprednisolone in an Experimental Compressive Spinal Cord Trauma Model

Celik, Haydar; Karatay, Mete; Erdem, Yavuz; Yildirim, Ali; Sertbas, Idris; Karatay, Eylem; Kuli, Halil; Guvenc, YAHYA; Koksal, Ismet; Menekse, Guner; Alagoz, Fatih; Kertmen, Huseyin; Caydere, Muzaffer

doi:10.5137/1019-5149.jtn.13210-14.1

The Biochemical, Histopathological and Clinical Comparison of the Neuroprotective Effects of Subcutaneous Adalimumab and Intravenous Methylprednisolone in an Experimental Compressive Spinal Cord Trauma Model

Atıf İçin Kopyala

Celik H., Karatay M., Erdem Y., Yildirim A. E., Sertbas I., Karatay E., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.26, sa.4, ss.622-631, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 4
Basım Tarihi: 2016
Doi Numarası: 10.5137/1019-5149.jtn.13210-14.1
Dergi Adı: TURKISH NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.622-631
Anahtar Kelimeler: Adalimumab, Methylprednisolone, Rats, Spinal cord injuries, TUMOR-NECROSIS-FACTOR, EARLY ULTRASTRUCTURAL FINDINGS, PRO-INFLAMMATORY CYTOKINE, GUILLAIN-BARRE-SYNDROME, LIPID-PEROXIDATION, FACTOR-ALPHA, OXIDATIVE STRESS, NERVOUS-SYSTEM, ISCHEMIA/REPERFUSION INJURY, RHEUMATOID-ARTHRITIS
Marmara Üniversitesi Adresli: Evet

Özet

AIM: To evaluate the neuroprotective effects of adalimumab in an experimental spinal cord injury model and compare them with those of the widely-used methylprednisolone.