Cefaclor, a cephalosporin antibiotic, delays gastric emptying rate by a CCK-A receptor-mediated mechanism in the rat


Bozkurt A., Deniz M., Yegen B.

BRITISH JOURNAL OF PHARMACOLOGY, vol.131, no.3, pp.399-404, 2000 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 3
  • Publication Date: 2000
  • Doi Number: 10.1038/sj.bjp.0703585
  • Title of Journal : BRITISH JOURNAL OF PHARMACOLOGY
  • Page Numbers: pp.399-404
  • Keywords: cephalosporins, gastric emptying, cholecystokinin (CCK), CCK-A receptors, capsaicin, STIMULATE CHOLECYSTOKININ SECRETION, PANCREATIC ENZYME SECRETION, TRYPSIN-INHIBITOR, DIABETIC GASTROPARESIS, FEEDBACK-REGULATION, SENSORY NEURONS, MONITOR PEPTIDE, BINDING-SITES, STC-1 CELLS, ERYTHROMYCIN

Abstract

1 Studies in vitro suggest that cephalosporin antibiotics release the gut hormone cholecystokinin. Cholecystokinin is known to inhibit gastric emptying. Here we examine the effects of cefaclor on gastric emptying and intestinal motility.