Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease

Ture-Ozdemir F., Tulunay A., Elbasi M. O., Tatli I., Maurer A., MUMCU G., ...Daha Fazla

RHEUMATOLOGY, cilt.52, sa.5, ss.800-805, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1093/rheumatology/kes399
  • Dergi Adı: RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.800-805
  • Anahtar Kelimeler: Behcet's disease, dendritic cells, inflammasome, neutrophils, pattern recognition receptors, INFECTIOUS ETIOLOGY, INNATE IMMUNITY, MANIFESTATIONS, PATHOGENESIS, ASSOCIATION, EXPRESSION, NOD2
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective. Activated innate immunity is implicated in the pathogenesis of Behcet's disease (BD). To clarify the mechanisms of innate immune responses, we investigated inflammasome activation in dendritic cells (DCs) and neutrophils, following stimulation with two different pattern recognition receptors (PRRs) RIG-1-like (RLR) and NOD-like (NLR) in patients with BD.